Nanometer-scale downstream virus control
Scalable virus-removal and prefiltration options for downstream bioprocessing.
A nominal 15–50 nm rating alone does not establish a validated virus-removal claim
Filter formats
The portfolio combines nanometer-scale virus-removal membranes with nylon and depth-prefilter options. Scalable formats support membrane screening, filterability evaluation, process sizing, validation studies and larger downstream batches.
Small-area syringe devices reduce sample consumption during early membrane screening, filterability checks and product-recovery assessment.
Best fit Screening and feasibility
Multiple pilot-scale membrane areas support optimization, scale-down modeling, prefilter-ratio studies and preparation for virus-clearance validation.
Best fit Development and validation
Production-scale cassettes support virus removal and prefiltration after filterability, compatibility, scaling and validation work has established the qualified process design space.
Best fit Pilot and manufacturing batches
Virus-removal and prefilter train selection
PES, regenerated-cellulose and multilayer virus-filtration media are available alongside nylon and cellulose-based depth prefilters. Dedicated prefilters can reduce aggregates, colloids and other fouling species before the virus-retentive membrane.
End-user applications
Virus-filter performance is highly dependent on feed composition, protein concentration, aggregate level, viscosity, pressure, temperature and processing time. Representative filterability and recovery studies should precede scale-up.
Virus-removal filtration in downstream purification of compatible antibody and recombinant-protein streams.
Virus-clearance steps for selected compatible plasma-derived and biological-product process streams.
Virus filtration within post-chromatography and final downstream polishing sequences.
Filterability evaluation, sizing and representative small-scale virus-clearance model development.
Nylon or depth prefiltration to manage foulants before the virus-retentive membrane.
Development and scale-up of compatible downstream filtration trains for additional biological products.
Filter-selection guidance
Confirm the prefilter-to-virus-filter area ratio experimentally. Virus-clearance validation should use a representative scale-down model, relevant model viruses, defined operating limits and a correlated integrity-test strategy.
Define the virus-clearance objective, regulatory strategy, target and model viruses, morphology and challenge design.
Provide protein concentration, viscosity, product-interaction risk and required recovery.
Characterize aggregate, colloid and particulate loading and the need for nylon or depth prefiltration.
Confirm expected throughput, processing time, flux, differential pressure and temperature.
Define the representative model, membrane-area scaling basis, and pre-use and post-use integrity-test criteria.
Assess acceptable yield loss, flush volume, hold-up volume, extractables and material compatibility.
Configuration matrix
Virus-removal, nylon-prefilter and depth-prefilter configurations are distinct product families. Not every medium, area or format is interchangeable. Confirm product binding, recovery, extractables, chemical compatibility, flush requirements and downstream effects using the actual process fluid.
| Media | General characteristics | Suggested applications |
|---|---|---|
| PES | Hydrophilic polyethersulfone membrane offering high liquid flow and compatibility with many aqueous biological streams | Small-scale virus-removal evaluation and compatible protein or biological-product solutions |
| Regenerated cellulose | Hydrophilic membrane selected where low nonspecific interaction and product recovery are important | Pilot-scale virus-removal studies and compatible protein-containing process fluids |
| Nylon | Hydrophilic membrane used as a prefilter to reduce selected particulates and membrane-fouling species | Prefiltration before virus-removal membranes |
| Cellulose / diatomaceous earth / nylon | Depth-prefilter matrix combining mechanical capture through the media thickness with adsorptive retention | Aggregate, colloid and foulant reduction before virus filtration |
| Purpose | Format | Media | Pore Size | Filtration area |
|---|---|---|---|---|
| Virus Removal | Syringe filter | PES | 15~50 nm | 2.5 cm² |
| Cassette-Pilot scale | RC | 0.015 / 0.08 / 0.3 / 0.5 m² | ||
| Cassette-Production scale | Multilayer virus-filtration membrane | 1.50 m² | ||
| Nylon Prefilter | Syringe filter | Nylon | 3.4 cm² | |
| Cassette-Pilot scale | 0.025 / 0.12 / 0.3 m² | |||
| Cassette-Production scale | 0.60 / 1.20 / 1.80 m² | |||
| Depth Prefilter | Syringe filter | Cellulose, Diatomite, Nylon | 4.5 cm² | |
| Cassette-Pilot scale | 0.027 / 0.15 / 0.4 m² | |||
| Cassette-Production scale | 0.92 / 1.1 m² 0.11 / 0.55 / 1.1 m² |
Confirm the clearance objective, representative feed, model-virus strategy, virus-removal medium, prefilter need, area ratio, throughput, pressure, recovery, scale-down model and integrity-test approach before submitting the final RFQ for technical review.