Critical liquid-process filtration
Hydrophilic membrane filtration for critical liquid-process steps.
A 0.2 µm pore rating does not by itself establish sterilizing-grade performance
Filter formats
The portfolio supports critical filtration of compatible aqueous, pharmaceutical and biological fluids. Scalable disc, capsule and cartridge formats cover membrane evaluation, process development, pilot processing and manufacturing, with enclosed single-use or reusable-housing configurations selected around the process.
Disc-format filters support membrane screening, bacterial-retention development, filterability testing and small-volume critical filtration.
Filtration area 10–20 cm²
Ready-to-connect capsules support critical liquid filtration at development, pilot and production scale when the selected grade and process are appropriately validated.
Available scale Development to production
Cartridges install in compatible reusable housings and support larger batches, established production systems and configurable sealing materials.
Housing interfaces DOE · 222 · 226
Membrane and pore-structure selection
PES, PVDF and nylon hydrophilic membranes are available with a 0.2 µm final layer. Single-layer and graded configurations allow the filtration train to be matched to relatively clean or more particulate-containing streams.
End-user applications
Membrane choice and filtration area should be confirmed using representative fluid, including throughput, product recovery, extractables risk and integrity-test suitability.
Critical filtration of compatible buffers and aqueous process solutions.
Filtration of compatible media, feeds and process additions.
Filtration of protein-containing and other biological process fluids.
Critical filtration of compatible small-molecule pharmaceutical fluids after compatibility and adsorption assessment.
Processing of vaccine, diagnostic and biopharmaceutical intermediates.
Bulk-product or formulation filtration and final filtration before aseptic transfer or filling when the selected grade is appropriately validated.
Filter-selection guidance
Small-area studies should compare membrane materials and graded configurations. Production sizing should include a suitable safety factor based on process variability and validated operating limits.
Define the required filtration claim and the product- and process-specific validation package.
Provide composition, viscosity, particle load, temperature and intended contact time.
Assess protein, active-ingredient or excipient adsorption, extractables risk and required recovery.
Confirm batch volume, processing-time target and maximum allowable differential pressure.
Define pre-use and post-use integrity testing, sterilization method and allowable number of cycles.
Identify connections, housing interfaces and single-use assembly compatibility.
Configuration matrix
Availability depends on the selected medium, pore structure, filtration area and filter format. Not every option is available in every combination. Membrane selection should account for product adsorption, extractables, fluid chemistry, sterilization method, temperature and contact time.
| Media | General characteristics | Suggested applications |
|---|---|---|
| PES | Hydrophilic membrane offering high liquid flow, easy wetting and low nonspecific protein adsorption | Buffers, media, protein solutions and general biological or pharmaceutical fluids |
| PVDF | Hydrophilic membrane with low protein adsorption and good mechanical and chemical resistance | Product-recovery-sensitive biological solutions and valuable process streams |
| Nylon | Naturally hydrophilic membrane with broad compatibility across many aqueous and chemical solutions | Small-molecule and low-fouling pharmaceutical fluids after compatibility and adsorption assessment |
| Format | Filtration area | Connection or end options |
|---|---|---|
| Disc-format filter | 10–20 cm² | 1/4–1/2 in. stepped hose barb |
| Capsule filter | 180–660 cm²; 0.25–3.2 m²; selected 0.8–2.4 m² configurations | 9/16, 3/4, 1-1/4 and 1-1/2 in. sanitary flanges; 3/8, 1/2, 9/16, 5/8, 3/4 and 1 in. stepped hose barbs; 1/4–1/2 and 1/4–3/8 in. multi-stepped hose barbs; selected 1-1/2 in. sanitary T-style connection |
| Cartridge filter | 180–660 cm²; 0.25–3.2 m² | Double open end, 222 and 226 end configurations; customizable O-ring options |
Confirm the required claim, fluid, membrane, pore structure, area, filter format, integrity-test strategy, sterilization method, connections and validation package before submitting the final RFQ for technical review.