Process clarification and particle control
Flexible removal of coarse and fine particles from life-science process streams.
Retention rating alone does not establish a microbial-retention or sterilizing-grade claim
Filter formats
The portfolio is designed to clarify life-science process fluids, remove suspended solids and protect downstream equipment and membrane filters. Disc, capsule and cartridge formats support screening through production-scale processing, with media selected around particle load, viscosity, chemical composition and sensitivity to product adsorption.
Disc-format filters support early evaluation of retention rating, media compatibility and filtration capacity while limiting sample consumption.
Filtration area 10–20 cm²
Capsules provide an enclosed fluid path for particle reduction from pilot through production scale, with multiple areas and connection choices.
Available scale Pilot to production
Cartridges fit compatible reusable housings and support repeated production campaigns with configurable end and sealing options.
Housing interfaces DOE · 222 · 226
Media and retention selection
PP, glass fiber, PES, PVDF, MCE and nylon media cover coarse clarification through fine particulate control. A tighter retention rating may increase particle removal but can reduce throughput when processing highly loaded fluids.
End-user applications
The required retention rating and filtration area should be established with representative fluid because particle-size distribution and fouling behavior can vary substantially between processes.
Clarification of buffers, media and other aqueous process solutions.
Removal of cell debris, aggregates, precipitates and suspended solids.
Prefiltration of cell-culture harvests and fermentation fluids.
Protection of chromatography, ultrafiltration, diafiltration and finer membrane filters.
Particle reduction in vaccine, protein, nucleic-acid, diagnostic and pharmaceutical workflows.
General laboratory filtration, filter sizing and production-fluid processing.
Filter-selection guidance
For highly loaded fluids, evaluate PP or glass-fiber media before tighter membrane media. Final sizing should use throughput and pressure-rise data generated with representative process material.
Define the target particle size, required filtrate clarity and intended process step.
Provide total particle load, particle-size distribution and the presence of colloids or aggregates.
State viscosity, product-recovery target, acceptable adsorption and other product sensitivities.
Confirm chemical composition, pH, operating temperature and intended contact time.
Define allowable differential pressure, desired processing time and required batch throughput.
Identify downstream protection needs, filter format, connections and housing compatibility.
Configuration matrix
Available retention ratings depend on the selected medium and filter format. Availability also depends on filtration area and connection choice; not every option is available in every combination.
| Media | General characteristics | Suggested applications |
|---|---|---|
| PP | Polypropylene-based medium offering broad compatibility, high dirt-holding capacity and low pressure drop | Coarse clarification, high-particle-load streams and protection of downstream filters |
| GF | Glass-fiber depth medium that captures a broad particle-size distribution within the filter structure | Cell-harvest clarification, media or serum prefiltration, and viscous or particle-laden fluids |
| PES | Hydrophilic membrane with high liquid flow and low nonspecific protein adsorption | Fine particle removal in buffers, media, biological solutions and protein-containing streams |
| PVDF | Hydrophilic options provide low protein adsorption and good mechanical and chemical resistance | Product-recovery-sensitive biological solutions and process intermediates |
| MCE | General-purpose hydrophilic membrane for economical aqueous particle retention | Routine clarification, particulate monitoring and general aqueous filtration |
| Nylon | Naturally hydrophilic membrane with broad compatibility across many aqueous and chemical solutions | Small-molecule solutions, low-fouling fluids and general process filtration |
| Format | Filtration area | Connection or end options |
|---|---|---|
| Disc-format filter | 10–20 cm² | 1/4–1/2 in. stepped hose barb |
| Capsule filter | 180–660 cm²; 0.25–3.2 m²; selected 0.8–2.4 m² configurations | 9/16, 3/4, 1-1/4 and 1-1/2 in. sanitary flanges; 3/8, 1/2, 9/16, 5/8, 3/4 and 1 in. stepped hose barbs; 1/4–1/2 and 1/4–3/8 in. multi-stepped hose barbs; selected 1-1/2 in. sanitary T-style connection |
| Cartridge filter | 180–660 cm²; 0.25–3.2 m² | Double open end, 222 and 226 end configurations; customizable O-ring options |
Confirm the target particle, fluid properties, media, retention rating, area, filter format, connections and processing limits before submitting the final RFQ for technical review.