Single-use mixing assemblies
Single-use mixing assemblies for rapid powder-liquid and liquid-liquid preparation without a permanently installed product-contact vessel.
Configuration based on batch conditions, mixing duty and matched support hardware
Product overview
The flexible container integrates a bottom impeller and the ports required to charge, mix, monitor, sample and discharge the batch. Installed in a compatible support and connected to the drive, the assembly operates as a closed product-contact system.
The bag, bottom impeller and process ports form a single-use mixing assembly for batch preparation.
Operating approach Closed single-use system
Multiple impeller geometries and materials support low-shear blending, high-torque powder dissolution and batch circulation.
Selection basis Process duty and fluid conditions
Mixer selection
Mixer selection should be based on batch size, minimum operating volume, viscosity, powder load, mixing-time target and shear sensitivity—not volume alone.
End-user applications
The portfolio supports powder-liquid and liquid-liquid preparation, process adjustment and shear-sensitive fluid handling.
Preparation of buffers, media and stock solutions for processing workflows.
Powder dissolution and controlled dilution of concentrates.
Liquid-liquid blending and batch standardization.
Preparation of downstream intermediates and formulations.
pH or conductivity adjustment followed by batch hold.
Handling of proteins and other shear-sensitive fluids.
Quotation preparation
Provide the batch conditions, required endpoint, hardware, fluid-path interfaces and discharge requirements needed for technical selection.
Provide target and minimum volume, viscosity, density, temperature and expected powder load.
State the dissolution, suspension, blending or homogenization duty and the required endpoint.
Identify the mixer support and drive, or request a matched bag-and-hardware recommendation.
List powder-port size, probe types, sampling, venting and every liquid line.
Define the drain location, acceptable residual volume and downstream connection.
Technical specification matrix
Use the matrix to define the assembly and prepare an RFQ. Final operating limits must follow the approved bag-and-mixer combination.
| Configuration area | Available choices | Selection purpose |
|---|---|---|
| Nominal volume | Selected designs from about 1 L to 3,000 L; common ready formats at 50, 100, 200, 500, 1,000, 1,500, 2,000, 2,500 and 3,000 L | Match batch size, minimum working volume and support hardware |
| Impeller system | Multiple bottom impeller styles; polypropylene or high-density polyethylene impellers with design-specific bearing materials | Balance flow, shear, torque, powder wet-out and maximum speed |
| Powder addition | 1.5, 3, 4 or 8 in sanitary powder ports with cap, gasket, blind cap and clamp options | Provide controlled charging of dry ingredients |
| Liquid lines | Platinum-cured silicone or weldable thermoplastic elastomer inlet and outlet lines | Support filling, recirculation, transfer and drain-down |
| Monitoring | Vertical, inclined or threaded electrode ports; thermowell or thermal sleeve; optional pH, conductivity or temperature interfaces | Track critical mixing conditions |
| Sampling | Needle-free swabable valve or sampling plug | Collect in-process samples while maintaining a closed path |
| Connections | Quick coupling, tubing plug, sanitary clamp or aseptic connector | Integrate the mixer with upstream and downstream equipment |
| Vent and filtration | Vent and filter connections available by assembly | Control air displacement and protect the closed boundary |
Confirm the batch range, mixing objective, impeller and hardware, ports, instruments and discharge strategy before technical review. Maximum impeller speed must follow the approved bag-and-mixer combination.