High-capacity process-stream clarification
High-capacity clarification and impurity reduction from laboratory to production scale.
Nominal depth grades are not absolute membrane pore sizes
Filter formats
Depth media capture contaminants throughout a porous matrix through size-based interception, entrapment and adsorptive interactions. Scalable enclosed formats support representative evaluation, primary and secondary clarification, and specialized polishing.
Small enclosed capsules support candidate-grade comparison, staged-filter evaluation, capacity testing and product-recovery assessment while minimizing sample use.
Best fit Screening and sizing
Process cassettes provide broad nominal retention and area options. Multiple grades can be arranged coarse-to-fine where staging improves capacity or filtrate quality.
Best fit Clarification trains
Compatible cartridge housings can use cellulose-, resin- and activated-carbon-containing options for clarification or selected color-body and organic-impurity reduction.
Best fit Specialized polishing
Retention-grade and staged-filter selection
Fine, intermediate and coarse grades support downstream membrane protection, secondary clarification and bulk solids removal. The correct grade or staged sequence should be established with representative feed using capacity, pressure, turbidity and recovery endpoints.
End-user applications
Capacity is strongly stream dependent. Representative trials should establish media grade, staged sequence, throughput, pressure endpoint, turbidity target and product recovery before production sizing.
Primary clarification of mammalian cell-culture harvests and compatible biological-product streams.
Clarification of microbial fermentation harvests, lysates and particle-laden intermediates.
Reduction of cells, cell debris, precipitates, aggregates and colloids.
Turbidity reduction before chromatography, concentration, bioburden-control, sterile, mycoplasma or virus filtration.
Polishing after centrifugation or an upstream coarse depth-filter stage.
Selected color-body or organic-impurity reduction using activated-carbon-containing media.
Filter-selection guidance
Screen candidate grades at small scale, identify the limiting process endpoint and size the production system with an appropriate safety factor and representative scale-down basis.
Define turbidity, solids concentration, particle-size distribution and variability across representative lots.
Confirm primary, secondary or polishing duty, target filtrate turbidity and downstream protection requirement.
Compare single grades and coarse-to-fine combinations for capacity, filtrate quality and process robustness.
Assess product concentration, adsorption risk, acceptable yield loss and recovery target.
Define required throughput per unit area, processing time, maximum differential pressure and filtration endpoint.
Confirm viscosity, temperature, pH, compatibility, flush volume, extractables, hold-up volume and production safety factor.
Configuration matrix
Retention grades and filtration areas are format dependent. Final availability must be confirmed for the selected medium and device size. Evaluate recovery, extractables, flush requirements, adsorption, pH, compatibility and pressure behavior with the actual process fluid.
| Media | General characteristics | Suggested applications |
|---|---|---|
| Cellulose, Diatomaceous earth, Resin | Fibrous structural matrix providing tortuous flow paths and mechanical depth capture | General clarification of cell harvests, fermentation streams, precipitates and process intermediates |
| Porous mineral component that increases internal surface area and supports particulate and colloid capture | Primary and secondary clarification of high-solids or high-turbidity streams | |
| Adsorptive component used to modify contaminant-binding and impurity-removal characteristics | Clarification and polishing where additional adsorptive retention is beneficial | |
| Activated carbon, Cellulose, Resin | High-surface-area adsorbent capable of binding selected color bodies and organic impurities | Specialized cartridge polishing where product compatibility and recovery have been demonstrated |
Depth-media components can interact with the target product as well as contaminants. Evaluate recovery, extractables, flush requirements, adsorption, pH and chemical compatibility, and pressure behavior with representative fluid.
| Format | Media | Nominal retention grade / range | Filtration area |
|---|---|---|---|
| Lab-scale capsule | Cellulose / diatomaceous earth / resin | 0.04–0.2 µm | 23 cm²–0.2 m² |
| Process-scale cassette | Cellulose / diatomaceous earth / resin | 0.04–0.2; 0.2–0.4; 0.4–0.6; 0.6–0.8; 0.8–1.5; 1.5–3.0; 3.0–6.0; 4.0–9.0; 5.0–12.0; 6.0–12.0; 6.0–15.0; 7.0–18.0; 7.0–30.0; 8.0–20.0; 0.02–0.2; 0.01–0.2; and 0.1–0.2 µm | 0.15–1.1 m² |
| Process-scale cartridge | Cellulose / activated carbon / resin | 0.5–1.0; 1.0–2.0; and 2.0–4.0 µm | 0.11–0.23 m² |
Confirm feed solids, clarification objective, target turbidity, candidate media, staged sequence, throughput, pressure endpoint, recovery, process conditions, scale-down basis and safety factor before submitting the final RFQ for technical review.