Membrane filtration for bioburden control
Scalable membrane-filtration solutions for clarification, particulate removal, prefiltration and bioburden control in life-science processing.
Pore size alone does not establish sterilizing-grade performance
Filter formats
The membrane-filtration portfolio is sourced from selected Chinese manufacturing partners and supports laboratory evaluation, pilot processing and production-scale filtration. Multiple media, pore-size combinations, filtration areas and connection options allow each filter to be configured around the fluid, batch volume, equipment interface and filtration objective.
Disc-format filters reduce sample and product consumption during initial membrane evaluation, filter sizing and development work.
Filtration area 10–20 cm²
Ready-to-connect capsules support laboratory, pilot and production systems with multiple filtration areas and connection options.
Available scale Lab to production
Cartridges install in compatible reusable filter housings and can be matched to different housing designs and process requirements.
Housing interfaces DOE · 222 · 226
Membrane and pore-size selection
PES, PVDF, MCE and nylon media are available in single-layer and graded multilayer configurations. The appropriate medium and filter size should be selected through compatibility and capacity testing with representative process fluid.
End-user applications
The portfolio supports aqueous, biological and pharmaceutical process streams where clarification, particulate management or protection of downstream equipment is required.
Removal of particles and suspended contaminants from aqueous process solutions.
Prefiltration of cell-culture media, feeds and streams upstream of finer membrane filters.
Bioburden control in non-final filtration steps under an approved process strategy.
Protection of chromatography, ultrafiltration and diafiltration operations.
Protein-containing solutions, vaccine and biopharmaceutical intermediates, and small-molecule solutions.
Laboratory screening, capacity studies and scale-up to larger capsule or cartridge formats.
Filter-selection guidance
Small-area filters should be used for initial screening and capacity studies before estimating the area required for larger capsule or cartridge configurations.
Define the required particle or bioburden reduction and the position of the filter in the process.
Provide composition, pH, temperature, contact time, viscosity and chemical-compatibility requirements.
State particle concentration, size distribution, and protein or active-ingredient concentration.
Confirm batch volume, desired processing time, acceptable product loss and required recovery.
Define maximum allowable differential pressure and other process-specific operating constraints.
Identify connections, housing interfaces and the cleaning, sterilization or single-use strategy.
Configuration matrix
Availability depends on the selected medium, pore size, filtration area and filter format. Not every option is available in every combination. Compatibility must be confirmed for the actual chemical composition, pH, temperature and contact time.
| Media | General characteristics | Suggested applications |
|---|---|---|
| PES | Hydrophilic membrane offering high liquid flow and low nonspecific protein adsorption | Buffers, culture media, biological solutions and protein-containing process fluids |
| PVDF | Hydrophilic options provide low protein adsorption and good mechanical and chemical resistance | Protein-sensitive solutions, biological intermediates and applications requiring high product recovery |
| MCE | General-purpose hydrophilic membrane for economical aqueous filtration | Routine clarification, particle retention and general aqueous filtration |
| Nylon | Naturally hydrophilic membrane with broad compatibility across many aqueous and chemical solutions | Small-molecule solutions, low-fouling fluids and general laboratory or process filtration |
| Format | Filtration area | Connection or end options |
|---|---|---|
| Disc-format filter | 10–20 cm² | 1/4–1/2 in. stepped hose barb |
| Capsule filter | 180–660 cm²; 0.25–3.2 m²; selected 0.8–2.4 m² configurations | 9/16, 3/4, 1-1/4 and 1-1/2 in. sanitary flanges; 3/8, 1/2, 9/16, 5/8, 3/4 and 1 in. stepped hose barbs; 1/4–1/2 and 1/4–3/8 in. multi-stepped hose barbs; selected 1-1/2 in. sanitary T-style connection |
| Cartridge filter | 180–660 cm²; 0.25–3.2 m² | Double open end, 222 and 226 end configurations; customizable O-ring options |
Confirm the filtration objective, process fluid, membrane, pore size, area, filter format, connections and qualification requirements before submitting the final RFQ for technical review.